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Article

Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults.

The Journal of nutrition - 1 Feb 2010

Phillips Catherine M, Goumidi Louisa, Bertrais Sandrine, Field Martyn R, Ordovas Jose M, Cupples L Adrienne, Defoort Catherine, Lovegrove Julie A, Drevon Christian A, Blaak Ellen E, Gibney Michael J, Kiec-Wilk Beata, Karlstrom Britta, Lopez-Miranda Jose, McManus Ross, Hercberg Serge, Lairon Denis, Planells Richard, Roche Helen M

Abstract excerpt

The leptin receptor (LEPR) is associated with insulin resistance, a key feature of metabolic syndrome (MetS). Gene-fatty acid interactions may affect MetS risk. The objective was to investigate the relationship among LEPR polymorphisms, insulin resistance, and MetS risk and whether plasma fatty acids, a biomarker of dietary fatty acids, modulate this. LEPR polymorphisms (rs10493380, rs1137100, rs1137101,...

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Topics

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Share to Fatty Acids, Omega-3
Share to Fatty Acids, Omega-6
Share to Fatty Acids, Unsaturated
Share to Hyperinsulinism
Share to Insulin
Share to Insulin Resistance
Share to Metabolic Syndrome
Share to Receptors, Leptin

Source

Identifiers

PMID: 20032477
DOI: 10.3945/jn.109.115329

Genes

LEPR
MAX

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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