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Article

Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance.

Nutrition, metabolism, and cardiovascular diseases : NMCD - 1 May 2012

Smith C E, Arnett D K, Corella D, Tsai M Y, Lai C Q, Parnell L D, Lee Y C, Ordovás J M

Abstract excerpt

BACKGROUND AND AIMS: Macronutrient intakes and genetic variants have been shown to interact to alter insulin resistance, but replications of gene-nutrient interactions across independent populations are rare, despite their critical importance in establishing credibility. We aimed to investigate a previously demonstrated saturated fat and carbohydrate interaction for insulin resistance for perilipin (PLIN1), a...

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Identifiers

PMID: 21193293
DOI: 10.1016/j.numecd.2010.09.003
PMCID: PMC3117106

Genes

PLIN1

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Related research

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Click a neighbor to travelStep 1 · 12 closest

Perilipin polymorphism interacts with saturated fat and carbohydrates to modulate insulin resistance.PMID 21193293Read ↗

Perilipin gene variation determines higher susceptibility to insulin resistance in Asian women when consuming a high-saturated fat, low-carbohydrate diet.Semantic proximity Read ↗

Perilipin polymorphism interacts with dietary carbohydrates to modulate anthropometric traits in hispanics of Caribbean origin.Semantic proximity Read ↗

Polymorphism PLIN1 11482 G>A interacts with dietary intake to modulate anthropometric measures and lipid profile in adults with normal-weight obesity syndrome.Semantic proximity Read ↗

Postprandial triacylglycerol metabolism is modified by the presence of genetic variation at the perilipin (PLIN) locus in 2 white populations.Semantic proximity Read ↗

Common variations in perilipin gene, central obesity, and risk of type 2 diabetes in US women.Semantic proximity Read ↗

Association between three genetic variants of the Perilipin Gene (PLIN) and glucose metabolism: results from a replication study among Chinese adults and a meta-analysis.Semantic proximity Read ↗

Gene-nutrient interactions in the metabolic syndrome: single nucleotide polymorphisms in ADIPOQ and ADIPOR1 interact with plasma saturated fatty acids to modulate insulin resistance.Semantic proximity Read ↗

Genetic variation at the perilipin (PLIN) locus is associated with obesity-related phenotypes in White women.Semantic proximity Read ↗

Genetic Variants in Lipid Metabolism Pathways Interact with Diet to Influence Blood Lipid Concentrations in Adults with Overweight and Obesity.Semantic proximity Read ↗

Modulation by dietary fat and carbohydrate of IRS1 association with type 2 diabetes traits in two populations of different ancestries.Semantic proximity Read ↗

Leptin receptor polymorphisms interact with polyunsaturated fatty acids to augment risk of insulin resistance and metabolic syndrome in adults.Semantic proximity Read ↗

Effects of perilipin (PLIN) gene variation on metabolic syndrome risk and weight loss in obese children and adolescents.Semantic proximity Read ↗

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