Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations.

doi:10.1007/s00401-013-1093-x

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Article

Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations.

Acta neuropathologica - 1 Mar 2013

Reuss David E, Piro Rosario M, Jones David T W, Simon Matthias, Ketter Ralf, Kool Marcel, Becker Albert, Sahm Felix, Pusch Stefan, Meyer Jochen, Hagenlocher Christian, Schweizer Leonille, Capper David, Kickingereder Phillipp, Mucha Jana, Koelsche Christian, Jäger Natalie, Santarius Thomas, Tarpey Patrick S, Stephens Philip J, Andrew Futreal P, Wellenreuther Ruth, Kraus Jürgen, Lenartz Doris, Herold-Mende Christel, Hartmann Christian, Mawrin Christian, Giese Nathalia, Eils Roland, Collins V Peter, König Rainer, Wiestler Otmar D, Pfister Stefan M, von Deimling Andreas

Abstract excerpt

Meningiomas are among the most frequent intracranial tumors. The secretory variant of meningioma is characterized by glandular differentiation, formation of intracellular lumina and pseudopsammoma bodies, expression of a distinct pattern of cytokeratins and clinically by pronounced perifocal brain edema. Here we describe whole-exome sequencing analysis of DNA from 16 secretory meningiomas and corresponding...

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Identifiers

PMID: 23404370
DOI: 10.1007/s00401-013-1093-x

Genes

KLF4
TRAF7

Variants

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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