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Article

Impact of host ageing on the metastatic phenotype.

Mechanisms of ageing and development - 1 Mar 2013

Meehan Brian, Dombrovsky Alexander, Lau Karrie, Lai Tiffany, Magnus Nathalie, Montermini Laura, Rak Janusz

Abstract excerpt

Ageing impacts multiple host mechanisms involved in cancer progression. Here we show that poorly metastatic Lewis lung carcinoma (LLC) cells form less bulky metastatic deposits in aged mice (>52 weeks) relative to their young (4-6 weeks) counterparts. Serial selection of LLC cells for increased m...

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Identifiers

PMID: 23403123
DOI: 10.1016/j.mad.2013.02.001

Genes

EPHA7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-23403123-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

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