Article
Spontaneous regression of advanced cancer: identification of a unique genetically determined, age-dependent trait in mice.
Proceedings of the National Academy of Sciences of the United States of America - 27 May 2003
Cui Zheng, Willingham Mark C, Hicks Amy M, Alexander-Miller Martha A, Howard Timothy D, Hawkins Gregory A, Miller Mark S, Weir Holly M, Du Wei, DeLong Cynthia J
Abstract excerpt
We have established and studied a colony of mice with a unique trait of host resistance to both ascites and solid cancers induced by transplantable cells. One dramatic manifestation of this trait is age-dependent spontaneous regression of advanced cancers. This powerful resistance segregates as a single-locus dominant trait, is independent of tumor burden, and is effective against cell lines from multiple types...
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