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Article

Engineering Artificial Antigen-presenting Cells to Express a Diverse Array of Co-stimulatory Molecules

20 Mar 2007

Abstract excerpt

To facilitate the therapeutic application of antigen-presenting cells (APCs), we have developed a cell-based artificial APC (aAPC) system by engineering K562 cells with lentiviruses to direct the stable expression and secretion of a variety of co-stimulatory molecules and cytokines. Here we report the use of a combinatorial lentiviral gene transfer approach to achieve long-term stable expression of at least seven...

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PMID: 17375070
DOI: 10.1038/mt.sj.6300134

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