Article
Ex vivo expansion of tumor specific lymphocytes with IL-15 and IL-21 for adoptive immunotherapy in melanoma.
Cancer letters - 18 Nov 2009
Huarte Eduardo, Fisher Jan, Turk Mary Jo, Mellinger Diane, Foster Cathy, Wolf Benita, Meehan Kenneth R, Fadul Camilo E, Ernstoff Marc S
Abstract excerpt
Although T central memory cells have been described as the most effective T-cell subtype against tumor growth, little is known about the requirements needed for their optimal ex vivo generation. Hence, our goal is to establish a protocol that will lead to consistent ex vivo generation of lymphocytes skewed toward a central memory phenotype. Antigen-specific T-cell lines were generated by ex vivo stimulation with...
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