Article
Response to succinylcholine in patients carrying the K-variant of the butyrylcholinesterase gene.
Anesthesia and analgesia - 1 Mar 2013
Bretlau Claus, Sørensen Martin Kryspin, Vedersoe Anne-Lise Zimling, Rasmussen Lars Simon, Gätke Mona Ring
Abstract excerpt
BACKGROUND: Succinylcholine is usually metabolized quickly by the butyrylcholinesterase enzyme (BChE) but genetic variants of BChE may prolong the duration of action. The Kalow (K) variant is the most common mutation in the butyrylcholinesterase gene (BCHE), being present in 25% of Caucasians. The significance of the K-variant for the duration of action of succinylcholine has not been well studied. Our hypothesis...
Topics
- Adult
- Aged
- Anesthesia Recovery Period
- Butyrylcholinesterase
- Female
- Genetic Variation
- Humans
- Male
- Middle Aged
- Mutation
- Prospective Studies