Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine.

Pharmacology & therapeutics - 1 Jan 1990

Lockridge O

Abstract excerpt

People with genetic variants of cholinesterase respond abnormally to succinylcholine, experiencing substantial prolongation of muscle paralysis with apnea rather than the usual 2-6 min. The structure of usual cholinesterase has been determined including the complete amino acid and nucleotide sequence. This has allowed identification of altered amino acids and nucleotides. The variant most frequently found in...

Topics

Amino Acid Sequence
Base Sequence
Cholinesterases
Genetic Variation
Humans
Molecular Sequence Data
Succinylcholine

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 2195556
DOI: 10.1016/0163-7258(90)90044-3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-2195556-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Genetic variants of human serum cholinesterase influence metabolism of the muscle relaxant succinylcholine.PMID 2195556Read ↗

Prolonged response to succinylcholine: a new variant of plasma cholinesterase that is identified as normal by traditional phenotyping methods.Semantic proximity Read ↗

Plasma cholinesterase and abnormal reaction to succinylcholine: twenty years' experience with the Danish Cholinesterase Research Unit.Semantic proximity Read ↗

[Cholinesterases].Semantic proximity Read ↗

Pseudocholinesterase deficiency: a comprehensive review of genetic, acquired, and drug influences.Semantic proximity Read ↗

Clinical importance of plasma cholinesterase for the anaesthetist.Semantic proximity Read ↗

Response to succinylcholine in patients carrying the K-variant of the butyrylcholinesterase gene.Semantic proximity Read ↗

Role of aspartate 70 and tryptophan 82 in binding of succinyldithiocholine to human butyrylcholinesterase.Semantic proximity Read ↗

Plasma cholinesterase: gene and variations.Semantic proximity Read ↗

Structural basis of the butyrylcholinesterase H-variant segregating in two Danish families.Semantic proximity Read ↗

[Prolonged succinylcholine-induced apnoea associated with cholinesterase silent plasma variant].Semantic proximity Read ↗

Congenital myasthenic syndrome due to a novel missense mutation in the gene encoding choline acetyltransferaseSemantic proximity Read ↗

Choline Acetyltransferase Mutations Causing Congenital Myasthenic Syndrome: Molecular Findings and Genotype-Phenotype Correlations.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.