Article

Pharmacogenetics and Anaesthesiology.

2004-06-01

Abstract excerpt

Pharmacogenetics was initiated in the 1950s by the observation of prolonged postoperative apnoea due to an inherited reduction in metabolism of the neuromuscular blocking agent succinylcholine. The enzyme butyrylcholinesterase is responsible for the hydrolysis of succinylcholine. Besides the normal (usual, U) variant, there are atypical (A), silent (S), fluoride-resistant (F), and J, K, and H variants of butyrylch...

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Literature Corpus work: 08a039f6-ef27-5b52-ad04-68c140d0bb8c
DOI: 10.2174/1570160043377592

Open publication

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