Article
Pharmacokinetics of intravenous voriconazole in obese patients: implications of CYP2C19 homozygous poor metabolizer genotype.
Pharmacotherapy - 1 Mar 2013
Moriyama Brad, Jarosinski Paul F, Figg William D, Henning Stacey A, Danner Robert L, Penzak Scott R, Wayne Alan S, Walsh Thomas J
Abstract excerpt
There is a paucity of pharmacokinetic studies describing weight-based dosing of intravenous voriconazole in obese patients. In this case report, we describe the pharmacokinetics of intravenous voriconazole in an obese CYP2C19 homozygous poor metabolizer and review previously reported data regarding the use of intravenous voriconazole in obese patients. A 17-year-old obese Hispanic male patient (body mass index...
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