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Article

Impact of the CYP2C19 genotype on voriconazole exposure in adults with invasive fungal infections.

Pharmacogenetics and genomics - 1 May 2017

Hamadeh Issam S, Klinker Kenneth P, Borgert Samuel J, Richards Ashley I, Li Wenhui, Mangal Naveen, Hiemenz John W, Schmidt Stephan, Langaee Taimour Y, Peloquin Charles A, Johnson Julie A, Cavallari Larisa H

Abstract excerpt

OBJECTIVES: Voriconazole, a first-line agent for the treatment of invasive fungal infections (IFIs), is metabolized by CYP2C19. A significant proportion of patients fail to achieve therapeutic trough concentrations with standard weight-based voriconazole dosing, placing them at increased risk for treatment failure, which can be life threatening. We sought to test the association between the CYP2C19 genotype and...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Cytochrome P-450 CYP2C19

Share to Dose-Response Relationship, Drug

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Share to Polymorphism, Single Nucleotide

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Source

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Identifiers

PMID: 28306618
DOI: 10.1097/FPC.0000000000000277
PMCID: PMC5391994

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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