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Identifying and Targeting ROS1 Gene Fusions in Non–Small Cell Lung Cancer

23 Aug 2012

Abstract excerpt

PURPOSE: Oncogenic gene fusions involving the 3' region of ROS1 kinase have been identified in various human cancers. In this study, we sought to characterize ROS1 fusion genes in non-small cell lung cancer (NSCLC) and establish the fusion proteins as drug targets. EXPERIMENTAL DESIGN: An NSCLC tissue microarray (TMA) panel containing 447 samples was screened for ROS1 rearrangement by FISH. This assay was also...

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PMID: 22919003
DOI: 10.1158/1078-0432.ccr-12-0550

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