Mutations of the<i>BRAF</i>gene in human cancer, by Davies<i>et al</i>. (<i>Nature</i>2002; 417: 949-54)

Abstract excerpt

Conflict of interest: none declared. It is now a decade since a multicentre, systematic, genome‐wide assessment of cancer‐associated pathways led to a major breakthrough in defining the molecular alterations associated with the development of sporadic cutaneous malignant melanoma (MM).1 Sporadic cancers occur because of the accumulation of mutations in essential genes that alter the normal functions of cell...

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