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Article

Muscarinic receptor subtype-specific effects on cigarette smoke-induced inflammation in mice.

The European respiratory journal - 1 Dec 2013

Kistemaker Loes E M, Bos I S T, Hylkema Machteld N, Nawijn Martijn C, Hiemstra Pieter S, Wess Jürgen, Meurs Herman, Kerstjens Huib A M, Gosens Reinoud

Abstract excerpt

Cholinergic tone contributes to airflow obstruction in chronic obstructive pulmonary disease. Accordingly, anticholinergics are effective bronchodilators by blocking the muscarinic M3 receptor on airway smooth muscle. Recent evidence indicates that acetylcholine also contributes to airway inflammation. However, which muscarinic receptor subtype(s) regulates this process is unknown. In this study, the contribution...

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PMID: 23397297
DOI: 10.1183/09031936.00112412

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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