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Article

Reduced inflammatory response in cigarette smoke exposed Mrp1/Mdr1a/1b deficient mice.

Respiratory research - 7 Jul 2007

van der Deen Margaretha, Timens Wim, Timmer-Bosscha Hetty, van der Strate Barry W, Scheper Rik J, Postma Dirkje S, de Vries Elisabeth G, Kerstjens Huib A

Abstract excerpt

BACKGROUND: Tobacco smoke is the principal risk factor for chronic obstructive pulmonary disease (COPD), though the mechanisms of its toxicity are still unclear. The ABC transporters multidrug resistance-associated protein 1 (MRP1) and P-glycoprotein (P-gp/MDR1) extrude a wide variety of toxic substances across cellular membranes and are highly expressed in bronchial epithelium. Their impaired function may...

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Share to ATP Binding Cassette Transporter, Subfamily B
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 17617921
DOI: 10.1186/1465-9921-8-49
PMCID: PMC1950505

Genes

TNF
MIP

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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