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Article

Interplay between type 1A topoisomerases and gyrase in chromosome segregation in Escherichia coli.

Journal of bacteriology - 1 Apr 2013

Usongo Valentine, Tanguay Cynthia, Nolent Flora, Bessong Jill Egbe, Drolet Marc

Abstract excerpt

Escherichia coli possesses two type 1A topoisomerases, Topo I (topA) and Topo III (topB). Topo I relaxes excess negative supercoiling, and topA mutants can grow only in the presence of compensatory mechanisms, such as gyrase mutations. topB mutants grow as well as wild-type cells. In vitro, Topo III, but not Topo I, can efficiently decatenate DNA during replication. However, in vivo, a chromosome segregation...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23396913
DOI: 10.1128/JB.02001-12
PMCID: PMC3624552

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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