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A role for topoisomerase III in E scherichia colichromosome segregation

16 Oct 2012

Abstract excerpt

The cellular function of Escherichia coli topoisomerase III remains elusive. We show that rescue of temperature-sensitive mutants in parE and parC (encoding the subunits of the chromosomal decatenase topoisomerase IV) at restrictive temperatures by high-copy suppressors is strictly dependent on topB (encoding topoisomerase III). Double mutants of parEΔtopB and parCΔtopB were barely viable, grew slowly, and were...

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PMID: 23066834
DOI: 10.1111/mmi.12039

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