Article
Association of IL27 gene polymorphisms and HBV-related hepatocellular carcinoma risk in a Chinese population.
Infection, genetics and evolution : journal of molecular epidemiology and evolutionary genetics in infectious diseases - 1 Jun 2013
Peng Qiliu, Qin Xue, He Yani, Chen Zhiping, Deng Yan, Li Taijie, Xie Li, Zhao Jinmin, Li Shan
Abstract excerpt
BACKGROUND AND OBJECTIVE: Hepatocellular carcinoma (HCC) is multifactorial, and the genetic background may be a crucial etiologic factor. Interleukin-27 (IL-27) is a novel IL-12 family member which plays an important role in antitumor immunity. Mutations in the IL27 gene may lead to altered cytokine production and/or activity and thus modulate individual's susceptibility to HCC. In this study, we investigated the...
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