Genetic polymorphism of interleukin-6 influences susceptibility to HBV-related hepatocellular carcinoma in a male Chinese Han population.

doi:10.1016/j.humimm.2014.02.006

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Article

Genetic polymorphism of interleukin-6 influences susceptibility to HBV-related hepatocellular carcinoma in a male Chinese Han population.

Human immunology - 1 Apr 2014

Tang Shengli, Yuan Yufeng, He Yueming, Pan Dingyu, Zhang Yongxi, Liu Yuanyuan, Liu Quanyan, Zhang Zhonglin, Liu Zhisu

Abstract excerpt

As a multifunctional cytokine, interleukin-6 (IL-6) plays a key role in chronic inflammation as well as tumor growth and progression of hepatitis B virus (HBV) infection. Recent studies have implicated that single nucleotide polymorphism (SNP) -572C>G (rs1800796) located within the promoter region of IL-6 gene was associated with susceptibility to several diseases. Here, a case-control study was undertaken to...

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PMID: 24530755
DOI: 10.1016/j.humimm.2014.02.006

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