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Article

RAB7L1 interacts with LRRK2 to modify intraneuronal protein sorting and Parkinson's disease risk.

Neuron - 6 Feb 2013

MacLeod David A, Rhinn Herve, Kuwahara Tomoki, Zolin Ari, Di Paolo Gilbert, McCabe Brian D, MacCabe Brian D, Marder Karen S, Honig Lawrence S, Clark Lorraine N, Small Scott A, Abeliovich Asa

Abstract excerpt

Recent genome-wide association studies have linked common variants in the human genome to Parkinson's disease (PD) risk. Here we show that the consequences of variants at 2 such loci, PARK16 and LRRK2, are highly interrelated, both in terms of their broad impacts on human brain transcriptomes of unaffected carriers, and in terms of their associations with PD risk. Deficiency of the PARK16 locus gene RAB7L1 in...

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Identifiers

PMID: 23395371
DOI: 10.1016/j.neuron.2012.11.033
PMCID: PMC3646583

Genes

VPS35

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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