Article
A Gly98Val mutation in the N-Myc downstream regulated gene 1 (NDRG1) in Alaskan Malamutes with polyneuropathy.
PloS one - 1 Jan 2013
Bruun Camilla S, Jäderlund Karin H, Berendt Mette, Jensen Kristine B, Spodsberg Eva H, Gredal Hanne, Shelton G Diane, Mickelson James R, Minor Katie M, Lohi Hannes, Bjerkås Inge, Stigen Oyvind, Espenes Arild, Rohdin Cecilia, Edlund Rebecca, Ohlsson Jennie, Cizinauskas Sigitas, Leifsson Páll S, Drögemüller Cord, Moe Lars, Cirera Susanna, Fredholm Merete
Abstract excerpt
The first cases of early-onset progressive polyneuropathy appeared in the Alaskan Malamute population in Norway in the late 1970s. Affected dogs were of both sexes and were ambulatory paraparetic, progressing to non-ambulatory tetraparesis. On neurologic examination, affected dogs displayed predominantly laryngeal paresis, decreased postural reactions, decreased spinal reflexes and muscle atrophy. The disease was...
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