Article
A deletion in the N-myc downstream regulated gene 1 (NDRG1) gene in Greyhounds with polyneuropathy.
PloS one - 22 Jun 2010
Drögemüller Cord, Becker Doreen, Kessler Barbara, Kemter Elisabeth, Tetens Jens, Jurina Konrad, Jäderlund Karin Hultin, Flagstad Annette, Perloski Michele, Lindblad-Toh Kerstin, Matiasek Kaspar
Abstract excerpt
The polyneuropathy of juvenile Greyhound show dogs shows clinical similarities to the genetically heterogeneous Charcot-Marie-Tooth (CMT) disease in humans. The pedigrees containing affected dogs suggest monogenic autosomal recessive inheritance and all affected dogs trace back to a single male. Here, we studied the neuropathology of this disease and identified a candidate causative mutation. Peripheral nerve...
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