Article
CfaE tip mutations in enterotoxigenicEscherichia coliCFA/I fimbriae define critical human intestinal binding sites
15 Jan 2009
Abstract excerpt
Enterotoxigenic Escherichia coli (ETEC) use colonization factors to attach to the human intestinal mucosa, followed by enterotoxin expression that induces net secretion and diarrhoeal illness. ETEC strain H10407 expresses CFA/I fimbriae, which are composed of multiple CfaB structural subunits and a CfaE tip subunit. Currently, the contribution of these individual fimbrial subunits in intestinal binding remains...