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Article

Polymorphisms of the kappa opioid receptor and prodynorphin genes: HIV risk and HIV natural history.

Journal of acquired immune deficiency syndromes (1999) - 1 May 2013

Proudnikov Dmitri, Randesi Matthew, Levran Orna, Yuferov Vadim, Crystal Howard, Ho Ann, Ott Jurg, Kreek Mary J

Abstract excerpt

OBJECTIVE: Studies indicate cross-desensitization between opioid receptors (eg, kappa opioid receptor, OPRK1) and chemokine receptors (eg, CXCR4) involved in HIV infection. Whether gene variants of OPRK1 and its ligand, prodynorphin (PDYN), influence the outcome of HIV therapy was tested. METHODS: Three study points, admission to the Women's Interagency HIV Study, initiation of highly active antiretroviral...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, CXCR4

Share to Receptors, Opioid, kappa

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Source

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Identifiers

PMID: 23392455
DOI: 10.1097/QAI.0b013e318285cd0c
PMCID: PMC3625517

Genes

OPRK1
PDYN
CXCR4

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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