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Article

Genetic polymorphisms in CX3CR1 predict HIV-1 disease progression in children independently of CD4+ lymphocyte count and HIV-1 RNA load.

The Journal of infectious diseases - 1 Jun 2005

Singh Kumud K, Hughes Michael D, Chen Jie, Spector Stephen A

Abstract excerpt

BACKGROUND: The impact of CX3CR1 polymorphisms on human immunodeficiency virus type 1 (HIV-1) pathogenesis is controversial, with conflicting reports of their role in disease progression in HIV-1-infected adults. METHODS: A cohort of 1055 HIV-1-infected children were genotyped for 2 CX3CR1 polymorphisms, V/I249 and T/M280, and their impact on HIV-1-related disease progression, including central nervous system...

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Share to CD4 Lymphocyte Count
Share to CX3C Chemokine Receptor 1

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Receptors, Chemokine

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Share to RNA, Viral

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Source

Identifiers

PMID: 15871132
DOI: 10.1086/430091

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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