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Article

STAT2 deficiency and susceptibility to viral illness in humans.

Proceedings of the National Academy of Sciences of the United States of America - 19 Feb 2013

Hambleton Sophie, Goodbourn Stephen, Young Dan F, Dickinson Paul, Mohamad Siti M B, Valappil Manoj, McGovern Naomi, Cant Andrew J, Hackett Scott J, Ghazal Peter, Morgan Neil V, Randall Richard E

Abstract excerpt

Severe infectious disease in children may be a manifestation of primary immunodeficiency. These genetic disorders represent important experiments of nature with the capacity to elucidate nonredundant mechanisms of human immunity. We hypothesized that a primary defect of innate antiviral immunity was responsible for unusually severe viral illness in two siblings; the proband developed disseminated vaccine strain...

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Identifiers

PMID: 23391734
DOI: 10.1073/pnas.1220098110
PMCID: PMC3581986

Genes

STAT2

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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