Article
The T open reading frame of human immunodeficiency virus type 1.
Journal of acquired immune deficiency syndromes - 1 Jan 1990
Cohen E A, Lu Y, Göttlinger H, Dehni G, Jalinoos Y, Sodroski J G, Haseltine W A
Abstract excerpt
Sequence analysis of multiple isolates of the human immunodeficiency virus type 1 (HIV-1) reveals the existence of a conserved open reading frame, designated T, that partially overlaps the tat, rev, and vpu coding sequences. Here we show that in vitro translation of RNA derived from this region of the viral genome yields a 17 kDa fusion protein, the result of a minus one frameshift event in the overlap between...
Topics
- Amino Acid Sequence
- Base Sequence
- DNA, Viral
- HIV-1
- Humans
- Molecular Sequence Data
- Mutation
- Plasmids
- Protein Biosynthesis
- RNA, Messenger
- RNA, Viral
- Transcription, Genetic