Article
MicroRNA-21 promotes cell transformation by targeting the programmed cell death 4 gene.
Oncogene - 17 Jul 2008
Lu Z, Liu M, Stribinskis V, Klinge C M, Ramos K S, Colburn N H, Li Y
Abstract excerpt
MicroRNAs (miRNAs) are small noncoding RNA molecules that negatively control expression of target genes in animals and plants. The microRNA-21 gene (mir-21) has been identified as the only miRNA commonly overexpressed in solid tumors of the lung, breast, stomach, prostate, colon, brain, head and neck, esophagus and pancreas. We initiated a screen to identify miR-21 target genes using a reporter assay and...
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