Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Outlier Kinase Expression by RNA Sequencing as Targets for Precision Therapy

5 Feb 2013

Abstract excerpt

Abstract Protein kinases represent the most effective class of therapeutic targets in cancer; therefore, determination of kinase aberrations is a major focus of cancer genomic studies. Here, we analyzed transcriptome sequencing data from a compendium of 482 cancer and benign samples from 25 different tissue types, and defined distinct “outlier kinases” in individual breast and pancreatic cancer samples, based on...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Cancer Genomics and Diagnostics
Share to Cancer-related Molecular Pathways
Share to Pancreatic and Hepatic Oncology Research

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 23384775
DOI: 10.1158/2159-8290.cd-12-0336

Provenance

PubMed metadata and Literature Corpus relationships.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Outlier Kinase Expression by RNA Sequencing as Targets for Precision TherapyPMID 23384775Read ↗

Pan-cancer proteogenomic investigations identify post-transcriptional kinase targetsSemantic proximity Read ↗

Tumor-Intrinsic Kinome Landscape of Pancreatic Cancer Reveals New Therapeutic ApproachesSemantic proximity Read ↗

HEPATOCELLULAR CARCINOMA KINOME ATLAS AS AN EMPLOYABLE INSTRUMENTED PERSONALIZED MEDICINESemantic proximity Read ↗

The Clinical Kinase Index: Prioritizing Understudied Kinases as Targets for the Treatment of CancerSemantic proximity Read ↗

The kinome 'at large' in cancer.Semantic proximity Read ↗

Tumor-specific Kinase Motif Enrichment Analysis Identifies Personalized Therapeutic Cancer TargetsSemantic proximity Read ↗

Kinome state is predictive of cell viability in pancreatic cancer tumor and stroma cell linesSemantic proximity Read ↗

Stage-specific protein-domain mutational profile of invasive ductal breast cancer.Semantic proximity Read ↗

Combined Cellular and Biochemical Profiling to Identify Predictive Drug Response Biomarkers for Kinase Inhibitors Approved for Clinical Use between 2013 and 2017Semantic proximity Read ↗

Targeting the Human Kinome for Cancer Therapy: Current PerspectivesSemantic proximity Read ↗

The Clinical Kinase Index: A Method to Prioritize Understudied Kinases as Drug Targets for the Treatment of Cancer.Semantic proximity Read ↗

Comprehensive analysis of PLKs expression and prognosis in breast cancer.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.