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Article

Modulation of cytokine release and gene expression by the immunosuppressive domain of gp41 of HIV-1.

PloS one - 1 Jan 2013

Denner Joachim, Eschricht Magdalena, Lauck Michael, Semaan Marwan, Schlaermann Philipp, Ryu Hyunmi, Akyüz Levent

Abstract excerpt

The transmembrane envelope protein gp41 of the human immunodeficiency virus HIV-1 plays an important role during infection allowing fusion of the viral and cellular membrane. In addition, there is increasing evidence that gp41 may contribute to the immunodeficiency induced by HIV-1. Recombinant gp41 and a synthetic peptide corresponding to a highly conserved domain in gp41, the immunosuppressive (isu) domain,...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23383108
DOI: 10.1371/journal.pone.0055199
PMCID: PMC3559347

Genes

CXCL9
FCN1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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