Article

The Transmembrane Envelope Protein of Porcine Endogenous Retroviruses Modulates Cytokine Release and Gene Expression in Human Immune Cells

2026-08-14

Abstract excerpt

Porcine endogenous retroviruses (PERVs), their transmembrane envelope protein p15E and peptides corresponding to a highly conserved among all retroviruses domain in p15E, the immunosuppressive (isu) domain, demonstrated immunosuppressive properties. They inhibited in vitro immune reactions, and induced release of IL-6 and IL-10 in human peripheral blood mononuclear cells (PBMCs). We recently showed that p15E of PE...

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Literature Corpus work: d9d257a7-e189-54eb-aa3d-756b37b9ad7d
DOI: 10.20944/preprints202608.0940.v1

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