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Article

P-Rex1 Cooperates with PDGFRβ to Drive Cellular Migration in 3D Microenvironments

30 Jan 2013

Abstract excerpt

Expression of the Rac-guanine nucleotide exchange factor (RacGEF), P-Rex1 is a key determinant of progression to metastasis in a number of human cancers. In accordance with this proposed role in cancer cell invasion and metastasis, we find that ectopic expression of P-Rex1 in an immortalised human fibroblast cell line is sufficient to drive multiple migratory and invasive phenotypes. The invasive phenotype is...

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PMID: 23382862
DOI: 10.1371/journal.pone.0053982

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