Article
Virulence in lymphomagenesis is modulated by alterations in proteins binding to CORE and GRE-LVa elements of the MoMuLV enhancer.
Leukemia - 1 Jan 1992
Yuen P H, Khang Y H, Matherne C
Abstract excerpt
Changing nucleotide 3 of the CORE consensus from T to C has no effect on the binding of a 42 kDa protein, which has little affinity for the CCAAT binding site. Changing nucleotide 6 of the CORE consensus from T to C significantly reduces binding of the 42 kDa protein. Studies on the pathology induced by various MoMuLV mutants with CORE mutations showed that the CORE elements are important in modulating virulence...
Topics
- Animals
- Base Sequence
- Binding Sites
- Enhancer Elements, Genetic
- Lymphoma, T-Cell
- Mice
- Mice, Inbred BALB C
- Molecular Sequence Data
- Moloney murine leukemia virus
- Mutation
- Viral Core Proteins