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Article

Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers.

Molecular and cellular biology - 1 Jan 1992

Wang S W, Speck N A

Abstract excerpt

The Moloney murine leukemia virus causes thymic leukemias when injected into newborn mice. A major genetic determinant of the thymic disease specificity of the Moloney virus genetically maps to two protein binding sites in the Moloney virus enhancer, the leukemia virus factor b site and the adjacent core site. Point mutations introduced into either of these sites significantly shifts the disease specificity of...

Topics

Base Sequence
Binding Sites
Chromatography, Affinity
DNA, Viral
DNA-Binding Proteins
Electrophoresis, Polyacrylamide Gel
Enhancer Elements, Genetic
Hydrogen-Ion Concentration
Leukemia Virus, Murine
Molecular Sequence Data

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Mutation

Protein Denaturation

Viral Proteins

Source

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Identifiers

PMID: 1309596
DOI: 10.1128/mcb.12.1.89-102.1992
PMCID: PMC364072

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Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 29 Aug 2026. Prepared record publication-1309596-2026-08-29.1. Manifest publication-graph-cohort-2026-08-29.1.

Source receipt: PubMed via Helena Literature Corpus, retrieved 29 Aug 2026.

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Purification of core-binding factor, a protein that binds the conserved core site in murine leukemia virus enhancers.PMID 1309596Read ↗

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