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Article

Molecular architecture of the regulatory Locus sae of Staphylococcus aureus and its impact on expression of virulence factors.

Journal of bacteriology - 1 Nov 2003

Steinhuber Andrea, Goerke Christiane, Bayer Manfred G, Döring Gerd, Wolz Christiane

Abstract excerpt

We characterized the sae operon, a global regulator for virulence gene expression in Staphylococcus aureus. A Tn917 sae mutant was obtained by screening a Tn917 library of the agr mutant ISP479Mu for clones with altered hemolytic activity. Sequence analysis of the sae operon revealed two additional open reading frames (ORFs) (ORF3 and ORF4) upstream of the two-component regulatory genes saeR and saeS. Four...

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Identifiers

PMID: 14563862
DOI: 10.1128/JB.185.21.6278-6286.2003
PMCID: PMC219404

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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