Article
Importance of the global regulators Agr and SaeRS in the pathogenesis of CA-MRSA USA300 infection.
PloS one - 2 Dec 2010
Montgomery Christopher P, Boyle-Vavra Susan, Daum Robert S
Abstract excerpt
CA-MRSA infection, driven by the emergence of the USA300 genetic background, has become epidemic in the United States. USA300 isolates are hypervirulent, compared with other CA- and HA-MRSA strains, in experimental models of necrotizing pneumonia and skin infection. Interestingly, USA300 isolates also have increased expression of core genomic global regulatory and virulence factor genes, including agr and saeRS....
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