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Contribution of hla Regulation by SaeR to Staphylococcus aureus USA300 Pathogenesis

14 Jun 2019

Abstract excerpt

The SaeRS two-component system in Staphylococcus aureus is critical for regulation of many virulence genes, including hla , which encodes alpha-toxin. However, the impact of regulation of alpha-toxin by Sae on S. aureus pathogenesis has not been directly addressed. Here, we mutated the SaeR-binding sequences in the hla regulatory region and determined the contribution of this mutation to hla expression and...

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PMID: 31209148
DOI: 10.1128/iai.00231-19

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