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Article

A human tRNA methyltransferase 9-like protein prevents tumour growth by regulating LIN9 and HIF1-α.

EMBO molecular medicine - 1 Mar 2013

Begley Ulrike, Sosa Maria Soledad, Avivar-Valderas Alvaro, Patil Ashish, Endres Lauren, Estrada Yeriel, Chan Clement T Y, Su Dan, Dedon Peter C, Aguirre-Ghiso Julio A, Begley Thomas

Abstract excerpt

Emerging evidence points to aberrant regulation of translation as a driver of cell transformation in cancer. Given the direct control of translation by tRNA modifications, tRNA modifying enzymes may function as regulators of cancer progression. Here, we show that a tRNA methyltransferase 9-like (hTRM9L/KIAA1456) mRNA is down-regulated in breast, bladder, colorectal, cervix and testicular carcinomas. In the...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23381944
DOI: 10.1002/emmm.201201161
PMCID: PMC3598078

Genes

LIN9

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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