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Spermine synthase and MYC cooperate to maintain colorectal cancer cell survival by repressing Bim expression

26 Jun 2020

Abstract excerpt

Dysregulation of polyamine metabolism has been linked to the development of colorectal cancer (CRC), but the underlying mechanism is incompletely characterized. Here, we report that spermine synthase (SMS), a polyamine biosynthetic enzyme, is overexpressed in CRC. Targeted disruption of SMS in CRC cells results in spermidine accumulation, which inhibits FOXO3a acetylation and allows subsequent translocation to...

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PMID: 32591507
DOI: 10.1038/s41467-020-17067-x

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