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Article

Potent in vitro antibacterial activity of DS-8587, a novel broad-spectrum quinolone, against Acinetobacter baumannii.

Antimicrobial agents and chemotherapy - 1 Apr 2013

Higuchi Saito, Onodera Yoshikuni, Chiba Megumi, Hoshino Kazuki, Gotoh Naomasa

Abstract excerpt

We investigated the in vitro activity of DS-8587, a novel fluoroquinolone, against Acinetobacter baumannii. The MICs of DS-8587 against clinical isolates and its inhibitory activity against target enzymes were superior to those of ciprofloxacin and levofloxacin. Furthermore, the antibacterial activity of DS-8587 was less affected by adeA/adeB/adeC or abeM efflux pumps than was that of ciprofloxacin and the...

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Identifiers

PMID: 23380726
DOI: 10.1128/AAC.02374-12
PMCID: PMC3623304

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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