Article
A mitochondrial DNA variant associated with left ventricular hypertrophy in diabetes.
Biochemical and biophysical research communications - 19 Dec 2003
Momiyama Yukihiko, Furutani Michiko, Suzuki Yoshihiko, Ohmori Reiko, Imamura Shin-ichiro, Mokubo Atsuko, Asahina Takayuki, Murata Chisato, Kato Kiyoe, Anazawa Sonoko, Hosokawa Kazuhiro, Atsumi Yoshihito, Matsuoka Kempei, Kimura Mitsuru, Kasanuki Hiroshi, Ohsuzu Fumitaka, Matsuoka Rumiko
Abstract excerpt
Diabetes was reported to be associated with a mitochondrial (mt) DNA mutation at 3243 and variants at 1310, 1438, 3290, 3316, 3394, 12,026, 15,927, and 16,189. Among these mtDNA abnormalities, those at 3243, 3316, 15,927, and 16,189 were also suggested to cause cardiomyopathies. We investigated the prevalence of such mtDNA abnormalities in 68 diabetic patients with LV hypertrophy (LVH), 100 without LVH, and 100...
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