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Article

Aging and high concentrations of glucose potentiate injury to mitochondrial DNA.

Free radical biology & medicine - 1 Dec 1999

Fukagawa N K, Li M, Liang P, Russell J C, Sobel B E, Absher P M

Abstract excerpt

Deletions of mitochondrial DNA (mtDNA) are associated with aging and several chronic diseases. We have reported heterogeneous mutations between base pair 8468 and 13446 in mtDNA, the region known as the "common" deletion, in muscle of older humans with impaired glucose tolerance or diabetes mellitus. To further characterize potential effects of age and glycemia on mtDNA integrity, we studied corpulent JCR:LA-cp...

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Identifiers

PMID: 10641738
DOI: 10.1016/s0891-5849(99)00189-6

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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