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Increased double strand breaks in diabetic β-cells with a p21 response that limits apoptosis

18 Dec 2019

Abstract excerpt

DNA damage and DNA damage response (DDR) pathways in β-cells have received little attention especially in the context of type-2 diabetes. We postulate that p21 plays a key role in DDR by preventing apoptosis, associated through its overexpression triggered by DNA stand breaks (DSBs). Our results show that β-cells from chronic diabetic mice had a greater extent of DSBs as compared to their non-diabetic...

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PMID: 31852915
DOI: 10.1038/s41598-019-54554-8

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