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Article

KCNJ5 mutations in aldosterone producing adenoma and relationship with adrenal cortex remodeling.

Molecular and cellular endocrinology - 22 May 2013

Boulkroun Sheerazed, Golib Dzib José-Felipe, Samson-Couterie Benoit, Rosa Fabio Luiz Fernandes, Rickard Amanda Jane, Meatchi Tchao, Amar Laurence, Benecke Arndt, Zennaro Maria-Christina

Abstract excerpt

Somatic mutations of KCNJ5, coding for the potassium channel GIRK4, have recently been implicated in the formation of aldosterone producing adenoma (APA). While a causal link between KCNJ5 mutations, membrane depolarization and aldosterone production has been established, the precise mechanism by which these mutations promote cell proliferation and APA formation remains unclear. The aim of our study was to...

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Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 23376008
DOI: 10.1016/j.mce.2013.01.018

Genes

KCNJ5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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