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Article

KCNJ5 Mutations: Sex, Salt and Selection.

Hormone and metabolic research = Hormon- und Stoffwechselforschung = Hormones et metabolisme - 1 Dec 2015

Williams T A, Lenders J W M, Burrello J, Beuschlein F, Reincke M

Abstract excerpt

Somatic mutations have been identified in the KCNJ5 gene (encoding the potassium channel GIRK4) in aldosterone-producing adenomas (APA). Most of these mutations are located in or near the selectivity filter of the GIRK4 channel pore and several have been shown to lead to the constitutive overproduction of aldosterone. KCNJ5 mutations in APA are more frequent in women; however, this gender dimorphism is a reported...

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Share to Adenoma
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Share to G Protein-Coupled Inwardly-Rectifying Potassium Channels

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Sodium Chloride, Dietary

Source

Identifiers

PMID: 26566104
DOI: 10.1055/s-0035-1565090

Genes

KCNJ5

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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