Article
BRCA1 gene mutations frequency estimation by allele-specific real-time PCR of pooled genomic DNA samples.
Breast (Edinburgh, Scotland) - 1 Aug 2013
Anisimenko Maksim S, Mitrofanov Dmitriy V, Chasovnikova Olga B, Voevoda Mikhail I, Kovalenko Sergey P
Abstract excerpt
The frequencies of four mutations in the BRCA1 gene (185delAG, T300G, 4153delA, and 5382insC) were estimated in the Russian population. The mutations were analyzed in 7920 DNA samples obtained from randomly selected Novosibirsk citizens and 570 samples from breast cancer patients at Siberian hospitals. The mutations were detected by allele-specific real-time PCR. The mutation analysis was performed with pooled...
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