Article
Prevalence of the most frequent BRCA1 mutations in Polish population.
Journal of applied genetics - 1 Aug 2011
Brozek Izabela, Cybulska Celina, Ratajska Magdalena, Piatkowska Magdalena, Kluska Anna, Balabas Aneta, Dabrowska Michalina, Nowakowska Dorota, Niwinska Anna, Pamula-Pilat Jolanta, Tecza Karolina, Pekala Wioletta, Rembowska Jolanta, Nowicka Karina, Mosor Maria, Januszkiewicz-Lewandowska Danuta, Rachtan Jadwiga, Grzybowska Ewa, Nowak Jerzy, Steffen Jan, Limon Janusz
Abstract excerpt
The purpose of our study was to establish the frequency and distribution of the four most common BRCA1 mutations in Polish general population and in a series of breast cancer patients. Analysis of the population frequency of 5382insC (c.5266dupC), 300T >G (p.181T >G), 185delAG (c.68_69delAG) and 3819del5 (c.3700_3704del5) mutations of the BRCA1 gene were performed on a group of respectively 16,849, 13,462, 12,485...
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