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Article

Frequency of three BRCA1 gene founder mutations in breast/ovarian cancer families from the Pomerania-Kujawy region of Poland.

Clinical genetics - 1 Dec 2003

Janiszewska H, Haus O, Lauda-Swieciak A, Pasińska M, Laskowski R, Szymański W, Górski B, Lubiński J

Abstract excerpt

A group of 63 families from the Pomerania-Kujawy region were analyzed for three BRCA1 gene Polish founder mutations, 5382insC, 300T>G, and 4153delA, because of breast (BrCa) and/or ovarian cancer (OvCa) history. The analysis was carried out by multiplex polymerase chain reaction method. BRCA1 mutation was revealed in nine (14%) families: in three (33%) of hereditary BrCa and OvCa families, in three (8%) of...

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Breast Neoplasms
BRCA1 gene
Genes, BRCA1
Genetic Testing
Mutation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Ovarian Neoplasms

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Identifiers

PMID: 14986830
DOI: 10.1046/j.1399-0004.2003.00178.x

Genes

BRCA1

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