Article
The MMP1 rs1799750 2G allele is associated with increased low back pain, sciatica, and disability after lumbar disk herniation.
The Clinical journal of pain - 1 Nov 2013
Jacobsen Line M, Schistad Elina I, Storesund Anette, Pedersen Linda M, Espeland Ansgar, Rygh Lars J, Røe Cecilie, Gjerstad Johannes
Abstract excerpt
OBJECTIVES: Previous studies indicate that genetic variants in genes encoding proteins like matrix metalloproteinase (MMP) enzymes may affect degeneration of the intervertebral disk. One such genetic variant is a single nucleotide polymorphism insertion in the promoter region of the MMP1 gene, that is, the MMP1 rs1799750 2G allele, which increases the MMP1 expression in vitro. In this study, we examined whether...
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